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In order to increase the statistical power of our analyses, we also included individuals with ASD and controls from the Autism Brain Imaging Data Exchange (ABIDE I and II) samples.

All details on inclusion criteria are available on the ABIDE Website ( and have been published elsewhere.

Previous studies in children and adolescents with ASD have implicated cerebellar morphological abnormalities in ASD.

The posterior lobe of the cerebellum is involved in cognition and connected to associative regions such as the prefrontal cortex and the superior temporal region, whereas the anterior cerebellum likely modulates sensory-motor cortex activity.

A sub-sample of 59 subjects underwent an eye tracking protocol in order to measure the fixation time allocated to the eye region.

We did not observe any difference in global cerebellar volumes between ASD patients and controls; however, regional analyses found a decrease of the volume of the right anterior cerebellum in subjects with ASD compared to controls.

Demographic and clinical characteristics of these participants are reported in Supplementary Material 2.

All methods were carried out in accordance with relevant guidelines and regulations: All experimental protocols that included French individuals with ASD were approved by local ethics committee (CPP Ile-de-France IX).

The cerebellum is implicated in social cognition and is likely to be involved in the pathophysiology of autism spectrum disorder (ASD).

The goal of our study was to explore cerebellar morphology in adults with ASD and its relationship to eye contact, as measured by fixation time allocated on the eye region using an eye-tracking device.

Two-hundred ninety-four subjects with ASD and controls were included in our study and underwent a structural magnetic resonance imaging scan.


 
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08-Jul-2017 02:20